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Wednesday, December 5, 2012
The New Head of Congress' Science and Tech Committee Sure Doesn't Seem to Like Science Much
Republican Unity Frays Amid Fiscal Cliff Tension
* Conservative Republicans say Boehner offering "tax hike"
* House Speaker leads purge of party dissidents from key committee
* Top Senate Republican stops short of endorsing Boehner plan
By David Lawder and Thomas Ferraro
WASHINGTON, Dec 4 (Reuters) - U.S. congressional Republicans had wanted to show a united front against President Barack Obama's demand for tax hikes, but their tenuous coalition showed signs of strain on Tuesday.
Just a day after House Speaker John Boehner unveiled a "fiscal cliff" counteroffer with some concessions on revenues, he faced a criticism from some conservatives and what appeared to be a wait-and-see approach from others.
As lawmakers voiced their opinions, Boehner presided over a purge of some Republicans regarded as party dissidents from plum House committee assignments. One of those ousted called the moves "petty" and "vindictive."
The infighting threatened to undermine Republicans' negotiating position as Congress and the White House try to avoid $600 billion worth of automatic tax hikes and spending cuts in the new year by reaching a landmark deal to shrink deficits.
The top U.S. Senate Republican offered only tepid support, stopping well short of endorsing Boehner's offer to increase revenues by $800 billion by eliminating tax deductions and credits.
"I think it is important that the House Republican leadership has tried to move the process forward," Senate Republican leader Mitch McConnell told reporters.
Many Republicans, especially the most conservative, see the offer as the very tax hike they pledged to avoid, even though it would not increase rates.
Obama stood firm on his demand that tax rates on the wealthiest must rise as part of a deal to avert the fiscal cliff.
CONSERVATIVES HOWL
Senator Jim DeMint, of South Carolina, a favorite of the anti-tax Tea Party movement, said the plan would "destroy jobs" and let Washington continue to grow U.S. deficits.
DeMint's comments, along with criticism from other conservative lawmakers, showed Boehner faces pressure to stand firm against raising taxes while some in his ranks believe he needs to do so to obtain the elusive common ground with Obama's Democrats.
"This isn't rocket science. Everyone knows that when you take money out of the economy (with tax hikes), it destroys jobs, and everyone knows that when you give politicians more money, they spend it," DeMint said.
"This is why Republicans must oppose tax increases and insist on real spending reductions that shrink the size of government and allow Americans to keep more of their hard-earned money," the South Carolina Republican said.
Republican Representative Tom Cole of Oklahoma - who last week suggested Republicans cave to Obama's demands to renew tax cuts for income of up to $250,000 while allowing those on higher income to expire next month - voiced support for Boehner.
"There is a difference between suggesting a play to the quarterback and tackling him when he runs something else," Cole said.
"I recognize that the speaker makes the final call and he has my complete support," Cole said, predicting Boehner will reach a bipartisan deal that's backed by most House Republicans.
"I sense cautious optimism," Cole said.
As for DeMint's comments, Cole said, "I have a lot of respect for Jim DeMint. But criticism has to be coupled with something that is political possible to be useful," Cole said.
The internal Republican disputes are a sign of frustration that Obama and his Democrats appear to have the upper hand, said Greg Valliere of the Potomac Research Group, which tracks Washington politics for institutional investors. All Obama needs to do is wait and taxes will rise, although that risks damaging the economy.
"Republicans realize they will get much of the blame if we go over the cliff. And as they game out the ultimate outcome - which inevitably will include major compromises - they are acting more frustrated in public," Valliere said.
COMMITTEE PURGE
Two of the most conservative House members also lashed out at Boehner's leadership after he led an effort to remove them from plum assignments on the House Budget Committee.
Representatives Tim Huelskamp of Kansas and Justin Amash of Michigan - both Tea Party favorites - said they were purged from the panel because they defied leadership too often to defend their conservative principles. Two other Republicans also lost assignments on other committees.
Both Amash and Huelskamp voted against last year's deal to raise the debt limit and cast the only Republican votes in the House Budget Committee against the budget plan this year authored by panel chairman Paul Ryan.
Huelskamp called his ouster "petty" and "vindictive."
"What this says is that dissent will not be tolerated, particularly conservative dissent," he told an audience at the conservative Heritage Foundation think tank.
He added that Boehner wanted to silence opposition to a deal that would raise taxes.
"I think this makes it very clear to conservatives that you're about to get run over. Sit down and just lump it," he said.
A senior House Republican aide said Boehner was not upset by pot shots from some within the party's ranks.
"DeMint is a member of the far right," the senior aide said. "You would prefer that he bite his lip and not offer his criticism. But I don't think it is going to have any impact on the dynamics."
Boehner anticipates that dozens in his party will vote against any deal, but still believes he can win a majority -- perhaps two-thirds -- of House Republicans, the aide said.
Also on HuffPost:
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Source: http://www.huffingtonpost.com/2012/12/04/republicans-fiscal-cliff_n_2241034.html
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Scientists find 'bully' genes in common childhood tumor
Monday, December 3, 2012
In a genome sequencing study of 74 neuroblastoma tumors in children, scientists at the Johns Hopkins Kimmel Cancer Center and the Children's Hospital of Philadelphia (CHOP) found that patients with changes in two genes, ARID1A and ARID1B, survive only a quarter as long as patients without the changes. The discovery could eventually lead to early identification of patients with aggressive neuroblastomas who may need additional treatments.
Neuroblastomas affect nerve tissue throughout the body and are the most common, non-blood cancer in children. "These cancers have a wide spectrum of clinical outcomes, with some that are highly curable and others very lethal," says Victor Velculescu, M.D., Ph.D., professor of oncology and co-director of the Cancer Biology Program at Johns Hopkins. "Part of the reason for this variety in prognosis may be due to changes in the ARID1A and ARID1B genes."
Velculescu said these powerful "bully" genes were not identified in other gene sequencing studies of neuroblastoma, most likely because the Johns Hopkins-CHOP researchers used sequencing and analytical methods that looked for larger, structural rearrangements of DNA in addition to changes in the sequence of individual chemical base-pairs that form DNA. A report of their work appears in the Dec. 2 issue of Nature Genetics.
Of the 74 tumors in the study, 71 were analyzed for both rearrangements and base-pair changes. Cancer-specific mutations were found in a variety of genes previously linked to neuroblastoma, including the ALK and MYCN genes. In eight of the 71 patients, the investigators found alterations in the ARID1A and ARID1B genes, which normally control the way DNA folds to allow or block protein production.
The children with ARID1A or ARID1B gene changes had far worse survival, on average, than those without the genetic alterations ? 386 days compared with 1,689 days. All but one of these patients died of progressive disease, including one child whose neuroblastoma was thought to be highly curable.
The scientists were also able to detect and monitor neuroblastoma-specific genetic changes in the blood of four patients included in the study, and correlated these findings to disease progression.
"Finding cancer-specific alterations in the blood could help clinicians monitor patients for relapse and determine whether residual cancer cells remain in the body after surgery," says Mark Sausen, a Johns Hopkins graduate student and one of the lead scientists involved in the research.
The Johns Hopkins-CHOP team plans to conduct further studies in larger groups of patients to confirm the ARID1A-ARID1B correlation to prognosis.
###
Johns Hopkins Medicine: http://www.hopkinsmedicine.org
Thanks to Johns Hopkins Medicine for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/125647/Scientists_find__bully__genes_in_common_childhood_tumor
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Tuesday, December 4, 2012
WeVideo Launches New Cloud-Based Video Editor, Integrates With Facebook, Instagram, Dropbox, Flickr & Google Drive
WeVideo launched to the public earlier this year after previously offering its cloud-based video editor to YouTube users. Now the startup is releasing a new update to the video editing product that is aimed at providing easy-to-use themes and drag-and-drop functionality for users.Source: http://feedproxy.google.com/~r/Techcrunch/~3/87OTEE1ZyDw/
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Omaha Vegan Drinks! | Vegan Omaha
Earlier this year I attended the March edition of ATX Vegan Drinks. It was a blast! They served Vegan White Russians (with a cherry no less)?and a few food trucks were stationed outside so you could stuff your face with whatever you were craving. It was a great time and everyone was having fun and being social. In the back of my mind, I?ve always wanted to have an Omaha Vegan Drinks, ever since the original Vegan Drinks in NYC has been so influential.
Well, this Halloween I was invited to go to Goth dancing at House of Loom and after having a couple drinks there, I knew it was the right spot for Omaha Vegan Drinks. Great drinks, wonderful decor, mellow lighting and a commitment to local?organizations. Everything fell?into place!
Awesome artwork by Amanda Chronister! http://www.amandachronister.com/
We set the first Vegan Drinks for November 29th, 2012. I expected a decent turnout but it exceeded my expectations. About 40 people showed up! Sure, we had our regular Meetupers, but we also attracted the veg curious and fans of House of Loom. Block 16 took 24 pre-orders on their amazing BBQ Seitan and Smoked Tofu Sandwiches and were kind enough to drop them off for us.
Great mood and atmosphere
House of Loom already had some Vegan mixed drinks, but they created a couple more just for us. My beloved Vegan White Russian is now a ?Coconut Almond Caucasian? and our?Straight?Edge friends have the amazing ?Ginger Beet? to swig down.
Pick Your Elixer
Coconut Almond Caucasian and Ginger Beet Virgin
Another thing that excited me was the amazing staff who did some research on Vegan?alcoholic?drinks and seem excited about learning new things. The owners, Brent Crampton?Ethan Bondelid, were very?enthusiastic?about the prospect of hosting Omaha Vegan Drinks. ?So much so that they?ve reserved the last Thursday of every?month for Omaha Vegan Drinks!
The first of many Coconut Almond Caucasians!
And if the faboulous staff, owners, location, food and patrons weren?t enough, regular Vegan Omahans Julianna Klepfer, Kelly Klepfer and Lindsey Cayer made the most amazing Vegan ?cheeze.? Their recipes were from the cookbook Artisan Vegan Cheese by Miyoko Schinner. The cheeses were all so unique and delicious!
Thank you ladies!
So thank you to everyone who organized and attended, I can?t wait for the next Omaha Vegan Drinks. Hope to see you there! ?Follow us at Omaha Vegan Drinks Facebook and Twitter.
?
Source: http://www.veganomaha.com/2012/12/omaha-vegan-drinks/
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Monday, December 3, 2012
Crime and punishment in Australian business ? naked capitalism
By Houses and Holes, who is a regular contributor at The Sydney Morning Herald, The Age and The Drum and is a former commentator atBusiness Spectator. He is also the co-author of The Great Crash of 2008 with Ross Garnaut. He edits MacroBusiness. Cross posted from MacroBusiness.
In his greatest work, Crime and Punishment, Fyodor Dostoyevsky tells the story of Rodion Raskolnikov and his decision to kill an unscrupulous pawn-broker for her cash. Raskolnikov is an aspiring medical student and he rationalises the murder by the greater good that the money can do if it is in his hands. What follows is the finest psychological thriller in world fiction as Raskolnikov is pursued by the authorities and his conscience alike across the ravaged landscape of Western rationalism.
Dostoyevski?s main theme and point was to attack the radical thinking of Russian nihilism; to cut ?a long story short, those politicians of his day that were driven by a credo that the ends justified the means so long as enough impoverished folk benefited. ?Dostoyevski was no communist.
But the story is broader still and holds important lessons also for capitalism. Indeed, radical rationalists in all forms are the book?s target, and that can just as easily apply to those on the Right as it can the Left.?Which is why Dostoyeski?s work has something to add to an assessment of the current state of Australian capitalism and business.?As an?entrepreneur?myself, I understand the compulsion to bend (and sometimes break, eek!) the rules, to push a business forward. Sometimes rules, legal or ethical, do get in the way of common sense business decisions and it is very easy, and sometimes actually right, to push back the boundaries for the personal and the greater good. But there is also the danger of?misjudgment by these ubermensch and over time these mistakes can add up to a softening of the values themselves.
We have just now a range of high-profile scenarios playing out in Australian capitalism that Dostoyevski may recognise as a symptom that something has gone more fundamentally wrong with the values that underpin a rules-based liberalism that balances the benefits of individual merit against the collective need for?behavioral?norms.?In the public sphere, the scandal engulfing the highest levels of the RBA amid bribery charges surrounding its note printing offshoots is a case in point. One has to question the process of accountability handled by the bank. According to Glenn Stevens last week, the RBA did not disclose the details of its internal investigations in 2007 to government until the story broke in the media in 2009. Nor did it ever refer the issues to the police. Ever since, the RBA has been dogged by accusations of obfuscation. Finally last week, the most senior RBA executive responsible, Ric Battellino, acknowledged in Parliament that the police should have been notified and Glenn Stevens admitted the bank?s handling of the affair ?was not good enough?. Is this enough accountability? I don?t know and Ric Battellino has retired anyway, perhaps taking some sting out of the fallout. But the fact remains, lack of transparency in a regulator can only erode business probity more widely.
In the private sector we have two other recent high-profile examples of unaccountable behaviour. The first has been the recent convulsion of blame-shifting to labour the cost blow-outs in the oil and gas sector. While labour costs have certainly played a role and unions have too, more important has been the decisions by executives to charge into moon-landing levels of capital spending all at once. As a result they have inflated asset prices, as well as input costs for everything from welders to tires. That many in this same sector so violently opposed the resource rent tax, which may well have eased some of this cost inflation, is one irony. The other is that we have seen this story before (it is called ?a bubble?) and it will hopefully culminate in a shareholder rebellion that holds those executives who have destroyed value to account.
The other recent example of unaccountable behaviour brings together both public and private spheres in the ongoing ?Qantas imbroglio where former CEO Geoff Dixon is attacking the national carrier?s current management with a view to destabilising it for his own purposes. This is all to the good and if the market backs a better strategy championed by Dixon then that?s progress. But doing this from the chairmanship of Tourism Australia, a taxpayer funded organisation that had very large commercial contracts with Qantas, is a conflict of interest, as Qantas management has made plain. As ?Tourism Australia moves to negotiate with a new commercial airline partner, how can the public have faith that its chairman has their best interest at heart? The response of Tourism Minister Martin Ferguson, that Tourism Australia has been cognisant all along of Mr Dixon?s interests in Qantas, is more confession than defense.
It?s not easy to tell if these examples represent a worsening of business probity in Australia. After all, a thin grey line between public and private benefits is certainly not new. In the lead up to the GFC there was a remarkable dissolution of boundaries between investment banking and former public servants as privatisation passed assets from public to private hands. Accompanying that reform, an open-door policy developed between senior public and private executive roles.
There is also the role of globalisation to consider. As Sell on News has described, American historian Philip Bobbitt sees three models for capitalism emerging in the form of?market states: laissez faire (America), managerial (Europe) and mercantile (Japan). ?These three types will contest, just as communism, democracy and fascism contested for control of the nation state. Democracy, by the way, will struggle in the market state because its organising principle is one dollar, one unit of power, not one voter, one unit of power. As countries become more beholden to flighty international capital, it may be that the pressure upon governments to do special deals is growing. And in a post-GFC context of demand deficit, ?there is a global push towards closer integration between big businesses and governments that protect them, with all of the ?behind closed doors? connections that that entails. This might give you the sense that, for the time being at least, the?Eastern market state which privileges connections (especially filial) over transparency and meritorcracy, is in the?ascendancy.
But Australian capitalism is, at the best of times, a boys club. I don?t mean that as a comment about gender but rather an assessment of how the culture of Australian business works. It is, much like a footy or cricket team, a gang of mates. Often times, deals get done by pulling favours, regulators move against businesses behind the scenes, most sectors are so concentrated that success is often a case of trading assets between friends and, more to the point for this discussion, accountability in both the public and private sphere?s of our version of the market state is administered with such delicacy that punishment more often than not looks like reward.
This is not without its benefits. Familiarity makes crises more manageable and solutions more swift in the finding. But it also comes with problems. Anyone familiar with Paul Kelly?s seminal work, The End of Certainty, ?will understand that liberal capitalism is only lightly tolerated in Australian society. The default position for the nation is a?noncompetitive, oligarchic business structure that unites big business and government in a productivity-killing partnership that perennially erode?s the nation?s standards of living. Who could deny such an undercurrent when the past few years has re-established an untouchable ?banking oligopoly with few offsets for the public, a clique of big miners that write their own tax rates and a car manufacturing sector on public life-support (that I agree with, to risk your wrath!) but for some reason must be kept secret.
If you want to have a functional liberal capitalist system, one that lays claim to the benefits generated by individual genius, innovation (and occasional pushing back of boundaries) then you must also lay claim to individual?responsibility when things get cocked up.?As FOMC member, Thomas Hoenig put it:
?a capitalistic economy ? if you really believe in its long-term benefits ? has cycles. People do make mistakes. See, the market is valuable not because it?s the smartest in the world, but because it?s the harshest. It captures mistakes and punishes and forces a correction. It?s when you then interfere with that that you allow the path to go off longer and the correction to be more severe and harder on people.? And that?s what you can?t lose sight of when you say you?re for Capitalism, but not really.
Ironically, I think Dostoyevski would get the point.
* * *
Lambert here. But would Dostoyevski agree?
Source: http://www.nakedcapitalism.com/2012/12/crime-and-punishment-in-australian-business.html
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Hiring Now: MSDSonline
Founded in 1996 and based in Chicago, MSDSonline is a leading provider of cost-effective, cloud-based compliance solutions that help businesses manage a variety of global Environmental, Health & Safety (EH&S) regulatory compliance requirements.
The company?s products and services are focused on streamlining hazardous chemical/MSDS management, reporting workplace injuries and illnesses, training employees and administering other critical EH&S information.
By leveraging cloud-based technologies, MSDSonline delivers enterprise-level functionality to help safety professionals at any-size business improve employee safety, improve compliance recordkeeping and reduce potential exposures to workplace hazards and risks. MSDSonline has been recognized for the last six years on Inc. magazine?s list of America?s 5,000 fastest-growing private companies.
Describe your company in one sentence. MSDSonline is a young, fast growing, fast moving, environmental health and safety software company located in downtown Chicago.
What is the work environment like at MSDSonline? The work environment is very open, collaborative and friendly. Our employees are bright, hard working and good team players. That?s the primary reason the company is growing so well. Our employees make MSDSonline the great place it is to work.
Our work environment is pretty collaborative so you will often see teams of people in meetings, working on projects together and there is always a lot of movement in the office. We have 170 employees, and almost all are located in our office in Chicago. While we all have specific responsibilities and work functions, I think it?s safe to say, for a company our size, most people know each other and get along exceptionally well.
How did you get into this field? Actually, MSDSonline started as a free website that was born out of a dot.com that failed in the late 1990?s.? I worked for the dot.com and after the dot.com bubble burst, I and a few others, quickly recognized that the opportunity with MSDSonline was greater than the original dot.com business. So in some ways it was an accident that I am here today. The early days were very difficult?because we didn?t have any revenue but luckily, we were patient, listened to our prospects and customers and over time, our employees have turned MSDSonline into the profitable, fast growing company that it is today.
What characteristics do you look for in job seekers when hiring?
While different jobs may require different technical skill sets, generally, MSDSonline is looking for smart, hard working, employees who are self motivated and work well with others. Generally, this requires good communication and people skills. No one wants to work with someone who isn?t fun to be around or isn?t a team player.
Any advice for job seekers looking to work in your industry? The best advice I can give someone is to look for a growing company in a growing industry. Growing companies produce career opportunities and career growth. When I started my career in the late 1980?s, the paper industry was booming. By the time I left in the late 1990?s, the paper industry that I was in was under a great deal of pressure from electronic media. The business segment I was in wasn?t growing and there was no real opportunity for advancement. You never want to be in a position where you have to wait for people to retire to be promoted. Growing companies allow for advancement as they expand.
Where is your field/industry headed? The software business in general and our segment of software specifically will continue to grow for the foreseeable future. This is one really bright spot in the US Economy.
Where do you see your company in five years? I see us continuing to expand our business and broadening our product and services offering to support our growing customer base. I fully expect us to continue to grow at a rapid pace over the next 5 years, mostly through organic growth.
How has technology changed or affected your business? Adoption of the Internet as a workplace tool has been the most important development in technology for our company. In 2000, many companies simply weren?t connected or didn?t allow their employees access to the internet in the workplace. Today, it?s not uncommon for employees to have access to the Internet at work. In fact, many can?t do their job without access to the Internet. This has allowed Software as a Service (SaaS) companies like ours to serve a much wider customer base, efficiently and cost effectively.
What are some of the things you do for fun when you are not working? I spend time with my family. My kids are into sports and I coach several of their sports teams, which keeps me really busy on the weekends, but I wouldn?t trade that for my own personal hobbies, which have taken a back seat to their activities in recent years.??? When I?m done coaching, I?ll have more time to play golf, paddle tennis, and snowboard, which I really enjoy.
How do you want to be remembered? I want to be remembered as a guy who had an impact on people?s lives in a positive way.? I want to help create jobs and career advancement for our employees and create stability and build wealth for their families. Probably most importantly, I want to be remembered as someone who surrounded himself with good people, and let them grow and learn from them as we build good things together.? Finally, I like to have fun, so I think it fine for people to remember that about me too.
See all MSDSonline jobs on hiredMYway.com here.
Stay social with MSDSonline.
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Source: http://blog.hiredmyway.com/hiring-now-msdsonline/
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